By Prof. Dr. B. J. Hoffer, L. Olson (auth.), Prof. Dr. Y. Mizuno, Prof. Dr. M. B. H. Youdim, Prof. Dr. D. B. Calne, Dr. R. Horowski, Prof. Dr. W. Poewe, Prof. Dr. P. Riederer (eds.)
Neurodegeneration is among the most crucial matters of the research now and within the coming twenty first century. Alzheimer's disorder is the prime reason for dementia within the aged humans and Parkinson's ailment is among the significant neurologic problems with the superiority among 1 and 2/1 000 inhabitants in complex nations. Many others are being affected by intractable neurodegener ative issues corresponding to amyotrophic lateral sclerosis, Huntington's illness, or spinocerebellar degeneration. No really potent therapy is obtainable for any of those neurodegenerative problems aside from Parkinson's affliction; even in Parkinson's affliction, nonetheless it's very unlikely to decelerate the illness strategy with the presently to be had therapy. it really is urgently had to boost new potent strategy to halt or decelerate the affliction technique in each one of these problems. contemporary boost within the molecular organic and molecular genetic approach has introduced us nice growth within the figuring out of etiology and pathogenesis of those issues, yet nonetheless it's not recognized how neurons are going to die in those issues. To discover the query, mutual cooperation and alternate of principles among easy scientists and scientific peoples are of maximum importance.
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Extra resources for Advances in Research on Neurodegeneration: 3 & 4
Likewise high doses of NGF have been reported to impair the performance of rats in the 36 D. , unpublished). Whether this decrease in learning behaviour in these rats were due to the possible establishment of aberrant projection or sprouting of the cholinergic neurons due to too much NGF is not clear at the moment. Is NGF then the only neurotrophic factor for the septal cholinergic neurons? The neurotrophins constitue a family of structurally related molecules which beside NGF include brain-derived neurotrophic facor (BDNF), neurotrophin3 (NT-3) and neurotrophin-4 (NT-4) (Glass and Yancopoulos, 1993).
Nature 368: 147-150 Friden P, Walus L, Watson P, Doctrow S, Kozarich J, Backman C, Bergman H, Hoffer B, Bloom F, Granholm A (1993) Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science 259: 373-377 The role of neurotrophic factors in neurodegeneration 41 Gage F, Kawaja MD, Fischer LJ (1991) Genetically modified cells: application for intracerebral grafting. Trends Neurosci 14: 328-333 Glass DJ, Yancopoulos GD (1993) The neurotrophins and their receptors. Trends Cell BioI 3: 262-268 Gnahn H, Hefti F, Heumann R, Schwab M, Thoenen H (1983) NGF-mediated increase of choline acetyltransferase (ChAT) in the neornatal rat forebrain: evidence for a physiological role of NGF in the brain.
1994). All of these mice show a complex but distinct picture of phenotypic changes in brain and in the peripheral nervous system and they even show behaviour alterations which all need to be studied in more detail in the near future. It is to be expected that the creation of these types of animal models in addition to others will help us to understand better the normal physiology of neurotrophic factors in brain. In addition they might also prove useful to analyse the possible pharmacological effects and the therapeutic potentials of neurotrophic factors in some of the neurodegenerative diseases affecting central neurons.